Create a new ISO from the modded folder.Replace the files in the folder game as instructed in the mod readme.
NOTE: if you use the custom common.rpf the initial logos won't show up and the game will directly load, if you have a black screen when the game is loading that's normal Let me know what you think and if you have found some bugs. Today I'm finally releasing a new update to my mod pack for GTA: IV, and it's huge.